This leaflet provides information on a course of chemotherapy called modified deGramont. The leaflet will explain what this is and when and how it is given. It will also tell you about common side effects that you may experience. Contact telephone numbers and details of how to obtain further information on modified deGramont are given at the end of the leaflet.
This leaflet should be read alongside the ‘General information for patients receiving chemotherapy’ folder. If you haven’t received this folder please ask your nurse for a copy.
What is modified deGramont chemotherapy?
This is a chemotherapy treatment which is named after Professor deGramont. Professor deGramont devised a method of giving chemotherapy. This method has since been modified and renamed as modified deGramont.
This chemotherapy treatment consists of two drugs:
These two drugs together are often called MdG for short.
Why am I having MdG?
Your doctor has prescribed this chemotherapy because it has been found to be effective in treating your type of cancer.
How often will I receive MdG?
For the treatment to be most effective, it is given at specific time intervals. There are known as cycles. It is usual to have a cycle of MdG every 2 weeks for between 6 and 12 cycles. Your doctor will discuss with you the exact number of cycles you will receive.
How will my chemotherapy be given?
To receive your chemotherapy you will need to have a fine tube put into a large vein in your upper arm. This tube is called a PICC line. Your PICC line is usually put in about a week before you start your chemotherapy. It will stay in for the whole course of your treatment. Your doctor will explain this to you in more detail. We also have a leaflet that tells you more about PICC lines.
The folinic acid will be given to you through a drip over 1 hour. The drip is connected to your PICC line. The folinic acid helps to make the 5-FU part of your treatment work better.
The 5-FU will be given to you in two parts:
How do I look after the portable pump?
We will tell you how your pump works and how to look after it. We will also give you written information.
How often will I need to come to the hospital?
To receive this chemotherapy you will need to visit the hospital 3 times in every 2 week cycle.
1st visit – Outpatient clinic appointment
You will have blood samples taken and we will check how you are feeling and discuss any problems you may have. This is so we can check how the chemotherapy is affecting you. If your blood results are satisfactory, your chemotherapy will be prescribed. This appointment is usually a few days before your chemotherapy appointment.
2nd visit - Chemotherapy appointment
At this appointment you will spend approximately 2 hours on one of the day case treatment areas. Please allow up to an hour longer for your first visit. We will give you your chemotherapy in a drip. You will go home with your portable pump.
3rd visit - Pump disconnection
This appointment is 2 days after your chemotherapy appointment. You will return to one of the day case treatment areas to have your pump disconnected. This should take about half an hour.
Can I bring relatives and friends with me?
You are welcome to bring someone to stay with you during your treatment. Space is limited so there is not usually room for more than one person. Treatment areas are not suitable for young children.
What are the possible side effects?
Most patients don’t have many side effects with this type of chemotherapy. The doctors, nurses and pharmacy team can give you advice or answer any questions you may have.
Hair loss
This chemotherapy should not make you lose your hair. However, some people experience some hair thinning. We have a leaflet that tells you more about coping with hair loss. Please ask your nurse for a copy.
Sickness
This chemotherapy does not usually make people feel sick. However we will give you some anti-sickness tablets to take in case this happens.
If you are sick more than once in 24 hours despite taking regular anti-sickness medicine when you are at home after your chemotherapy treatment, please contact Velindre Cancer Centre for advice. The telephone number is at the end of the leaflet.
Infection
You are at an increased risk of picking up infections because your white blood cells which help fight infections can be reduced by this treatment.
If you develop an infection whilst your white blood cells are low, you are at risk of sepsis, this can be life threatening.
Contact Velindre Cancer Centre immediately if you develop any signs of infection, for example flu like symptoms or a temperature above 37.5°centigrade or if your temperature is below 35.5°. The telephone number is at the end of the leaflet.
Diarrhoea
You may have diarrhoea with this chemotherapy. If this occurs it is important that you drink plenty of fluids. Medication is available to control diarrhoea. If you have 4 or more bowel movements in 24 hours above what is normal for you please contact Velindre Cancer Centre immediately. The telephone number is at the end of the leaflet.
Tiredness and fatigue
Chemotherapy can make you feel more tired than usual. It is important to listen to your body and rest if you need to, but to carry out your normal activities if you feel able. Some people find it beneficial to take gentle exercise as well as taking rest.
Sore mouth
Your mouth may become sore or you may notice small ulcers. Please follow the advice on caring for your mouth in the general chemotherapy leaflet. Your doctor may prescribe mouthwashes or medication to prevent or clear any infection.
Soreness to your hands and feet
You may experience mild pain, redness and swelling of your hands or feet. If this occurs we recommend using a non perfumed cream or lotion regularly. Please contact Velindre Cancer Centre if your hands or feet become painful.
Blood clots
A diagnosis of cancer can increase your risk of developing a blood clot (thrombosis), and having cancer treatment may increase this risk further. It is important to tell your doctor immediately if you have symptoms such as pain, redness and swelling in your leg, or breathlessness and chest pain.
Blood clots can be very serious. However, most clots can usually be successfully treated with drugs to thin the blood. Your doctor or nurse can give you more information.
Other side effects
Some patients experience sore or watery eyes. Please tell your doctor or nurse if this occurs.
Very rarely, people on this chemotherapy experience heart problems such as angina (chest pain) or palpitations. If you experience palpitations or shortness of breath please contact Velindre Cancer Centre. The telephone number is at the end of the leaflet. If you experience chest pain telephone 999.
Women sometimes find that chemotherapy treatment affects their periods. They could become heavier, lighter or even stop altogether.
It is important you do not become pregnant or father a child whilst having chemotherapy treatment as chemotherapy could damage the unborn baby.
This chemotherapy can increase your skin’s sensitivity to the sun. It is best to avoid strong sunlight, wear a hat and use a sun block.
Sometimes cancer drugs can have very serious side effects which rarely can be life threatening. It is important to inform Velindre cancer centre if you are concerned about any side-effects.
Manufacturer’s patient information leaflets
Velindre leaflets provide information about very common and commonly reported side-effects (we are unable to list all of the common side effects), for more information regarding these and the less common side-effects please refer to the manufacturers patient information leaflets, obtained from Velindre pharmacy and/or on the internet at www.medicines.org.uk. Sometimes patients may find these leaflets difficult to read however. Please ask if you would like a copy from your doctor or from Velindre pharmacy
Contact telephone numbers
Velindre Cancer Centre 029 2061 5888
Ask for the treatment helpline if you are unwell at home and need immediate advice at any time of the day or night. For example you should phone if you:
Pharmacy department 029 2061 5888 ext 6223
Monday – Friday 9am – 5pm for queries about your medicines
Macmillan freephone Helpline 0808 808 0000
Tenovus freephone 0808 808 1010
cancer helpline
This information is also available in Welsh
This leaflet was written by health professionals. The information contained in this leaflet is evidence based. It has been approved by doctors, nurses and patients. It is reviewed and updated every 2 years.